Key result
In cats, the chemoreceptor response to alternations of PCO2 was brisker than to PO2, and PCO2 was 2.9 times more effective than PO2 in producing discharge oscillations during normocapnic hypoxia.
Population
Cats (feline model)
Design
Preclinical
Authors
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Feline chemoreceptor data warrant human validation before clinical use; leaves open relative PCO2/PO2 roles in hypoxic oscillations.
In a feline model, PCO2 and PO2 are equally important in generating natural respiratory oscillations in chemoreceptor discharge during normocapnic hypoxia, but PO2 becomes less important when its mean level is raised.
Kumar et al. (1988) studied this question. Abrupt changes in alveolar gas tensions (PCO2 and PO2) was evaluated on Oscillations in the discharge of carotid chemoreceptors. In cats, the chemoreceptor response to alternations of PCO2 was brisker than to PO2, and PCO2 was 2.9 times more effective than PO2 in producing discharge oscillations during normocapnic hypoxia.
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