Key result
Early elevated troponin I in critically ill patients was independently associated with increased hospital mortality (adjusted OR 1.05 per doubling of TnI), but did not improve APACHE II risk prediction.
Why the study?
Does early plasma troponin I concentration predict hospital mortality in general ICU patients?
Population
1,494 general ICU index admissions in two general level 3 ICU departments in the United Kingdom.
Comparison
Plasma Troponin I concentration measured within… vs Patients without detectable TnI, or continuous…
Design
Cohort
Follow-up
Hospital stay
Authors
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Does not support adding TnI to APACHE II for ICU mortality prediction; hypothesis-generating for biomarker-enhanced models.
Cohort (n=1,494)
Yes
Does early plasma troponin I concentration predict hospital mortality in general ICU patients?
Odds Ratio: 1.05 (95% CI 1.01–1.09)
Absolute Event Rate: 37.3% vs 14.6%
p-value: p=0.003
While early troponin I is an independent predictor of hospital mortality in ICU patients, it does not improve the predictive performance of the APACHE II model, suggesting routine measurement is not warranted.
Docherty et al. (2017) conducted a cohort in Critical illness (n=1,494). Early plasma Troponin I (TnI) elevation vs. Undetectable or lower Troponin I levels was evaluated on Hospital mortality (OR 1.05, 95% CI 1.01-1.09, p=0.003). Early elevated troponin I in critically ill patients was independently associated with increased hospital mortality (adjusted OR 1.05 per doubling of TnI), but did not improve APACHE II risk prediction.
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