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A general and efficient nucleophilic difluoromethylation of carbonyl compounds (both enolizable and non‐enolizable aldehydes and ketones) has been achieved by using a nucleophilic (phenylsulfonyl)difluoromethylation‐reductive desulfonylation strategy. Difluoromethyl phenyl sulfone acts as a difluoromethyl anion (“CF2H–”) equivalent. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
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Prakash et al. (2005) studied this question.
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