Key result
Treatment with 30 μM 3,3′-Diindolylmethane (DIM) significantly reduced LPS-induced apoptosis in H9C2 cardiomyocytes from 19.11% to 9.03%.
Why the study?
Does 3,3'-Diindolylmethane reduce LPS-induced inflammatory response and apoptosis in H9C2 cardiomyocytes?
Population
H9C2 cardiomyocytes
Comparison
3,3'-Diindolylmethane for 24 h vs LPS alone (no DIM)
Design
Preclinical
Follow-up
24 h
Authors
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Supports DIM investigation in septic cardiomyopathy; hypothesis-generating from cardiomyocyte data.
Does 3,3'-Diindolylmethane reduce LPS-induced inflammatory response and apoptosis in H9C2 cardiomyocytes?
Absolute Event Rate: 9.03% vs 19.11%
p-value: p=<0.05
3,3'-Diindolylmethane demonstrates protective effects against LPS-induced inflammation and apoptosis in cardiomyocytes, highlighting its potential for treating septic cardiomyopathy.
Luo et al. (2018) studied Sepsis-induced cardiomyopathy (in vitro model). 3,3′-Diindolylmethane (DIM) vs. LPS alone was evaluated on Apoptosis rate (p=<0.05). Treatment with 30 μM 3,3′-Diindolylmethane (DIM) significantly reduced LPS-induced apoptosis in H9C2 cardiomyocytes from 19.11% to 9.03%.
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