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In the preparation of methyl methylpyrazinyl ketones by the sequence methyl‐pyrazinecarboxylic ester, amide, nitrile, to ketone, methylpyrazinecarbonitriles were found to react with phosphorus oxychloride forming tricyclic compounds related to “2‐methylquinoxaline orange”. 2‐Methylpyrazine‐6‐carbonitrile with methylmagnesium iodide underwent addition at one of the ring CN bonds. 2‐Methylquinoxaline reacted similarly with phosphorus oxychloride, and organomagnesium compounds. The methyl methylpyrazinyl ketone described in literature as the 2,6‐isomer was shown to be the 2,5‐isomer.
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Schwaiger et al. (1972) studied this question.
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