Key result
Sarcopenia was associated with a higher risk of orthostatic hypotension in elderly outpatients compared to those without sarcopenia (50.0% vs 23.0%; adjusted OR 7.80, 95% CI 1.77-34.45, p=0.007).
Why the study?
Orthostatic hypotension is a significant precursor to falls and injuries in elderly patients, but its association with sarcopenia required determination.
Does sarcopenia increase the risk of orthostatic hypotension in elderly outpatients?
Cross-Sectional (n=91)
Does sarcopenia increase the risk of orthostatic hypotension in elderly outpatients?
Odds Ratio: 7.8 (95% CI 1.77–34.45)
Absolute Event Rate: 50% vs 23%
p-value: p=0.007
Age-related sarcopenia is strongly associated with an increased risk of orthostatic hypotension in elderly outpatients, which may contribute to the increased incidence of falls in this population.
May indicate higher orthostatic hypotension risk in sarcopenic elderly outpatients; hypothesis-generating and should not yet change practice.
OBJECTIVES: This study aims to determine the association of sarcopenia with orthostatic hypotension (OH) which is a significant precursor to falls and related injuries in elderly patients. PATIENTS AND METHODS: A total of 91 outpatients (18 males, 73 females; mean age 79.3±4.0 years; range, 75 to 91 years) were prospectively enrolled and those who were eligible underwent comprehensive sarcopenia assessment including measurement of muscle mass, strength, physical performance, anthropometric measurements along with frailty tests. Patients classified as sarcopenic or non-sarcopenic based on these measurements underwent supine and standing blood pressure (BP) measurements. The frequency of OH was compared between the two groups. RESULTS: Of the 91 patients, 29 (31.9%) had sarcopenia. There was no statistical difference in measurements of functional tests which consisted of gait speed, timed up-and-go test and handgrip strength. However, timed sit-to-stand test values were higher in sarcopenic patients (18.2±7.9 vs. 15.0±5.1, p=0.04). Patients with sarcopenia developed OA and intolerance more often compared to the non-sarcopenic patients (n=15 [50.0%] vs. n=14 [23.0%], p<0.01 and n=13 [44.8%] vs. n=9 [15.3%], p<0.01, respectively). The adjusted odds ratio for sarcopenia was 7.80 (95% confidence interval 1.77-34.45), p=0.007. CONCLUSION: Age-related sarcopenia increases the risk of OA in the elderly. This may in part explain the increased incidence of falls and also help identification of risky elderly patients for orthostatic BP drops.
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Kudret Keskin (2021) conducted a cross-sectional in Orthostatic hypotension and sarcopenia (n=91). Sarcopenia vs. Non-sarcopenic was evaluated on Orthostatic hypotension (OR 7.80, 95% CI 1.77-34.45, p=0.007). Sarcopenia was associated with a higher risk of orthostatic hypotension in elderly outpatients compared to those without sarcopenia (50.0% vs 23.0%; adjusted OR 7.80, 95% CI 1.77-34.45, p=0.007).
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