Key result
Carotid artery stenting significantly lowered paraoxonase activity (P=0.0032) and increased arylesterase activity (P=0.0058) the day after the procedure.
Why the study?
Does carotid artery stenting alter antioxidant capacity and oxidative stress markers in patients with carotid artery stenosis?
Observational (n=43)
Does carotid artery stenting alter antioxidant capacity and oxidative stress markers in patients with carotid artery stenosis?
p-value: p=0.0032
Carotid artery stenting induces early changes in both enzymatic and nonenzymatic antioxidant defense mechanisms, which correlate with neurological deficit severity.
CAS may acutely alter antioxidant markers post-procedure; leaves open clinical relevance and need for prospective outcome trials.
The treatment of carotid artery stenosis is associated with the risk of complications, which may include stroke after carotid artery stenting (CAS) and myocardial infarction after carotid endarterectomy (CEA). The imbalance between prooxidative mechanisms and antioxidant capacity creates a milieu of factors, which may increase the risk of complications after endovascular procedures. We have examined 43 consecutive patients with carotid artery stenosis. Sera were analyzed for the activity of paraoxonase (PON) and arylesterase (ARE), sulfhydryl groups (SG), malondialdehyde (MDA), and conjugated dienes (CD) concentrations by means of spectrophotometric methods before and next day after CAS. We have found lowered PON (P= 0.0032), increase in ARE activity (P= 0.0058), and decrease in sulfhydryl groups concentration (P= 0.0267). No effect on absolute MDA and CD concentrations was observed. The degree of carotid artery stenosis correlated negatively with PON/ARE ratio after CAS (rS= −0.507,P= 0.0268). To conclude, CAS influences both enzymatic (differently, PON and ARE activity) and nonenzymatic antioxidant defense. Females are more susceptible to lipid peroxidation after CAS. PON/ARE ratio after CAS correlated with the degree of carotid artery stenosis. The changes (deltas) in ARE activity, SG, and MDA concentrations correlated with the severity of neurological deficit and disability.
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Michalak et al. (2016) conducted an observational in Carotid artery stenosis (n=43). Carotid artery stenting (CAS) vs. Baseline (before CAS) was evaluated on Activity of paraoxonase (PON) and arylesterase (ARE), sulfhydryl groups (SG), malondialdehyde (MDA), and conjugated dienes (CD) concentrations (p=0.0032). Carotid artery stenting significantly lowered paraoxonase activity (P=0.0032) and increased arylesterase activity (P=0.0058) the day after the procedure.