Key result
A preoperative granulocyte/lymphocyte ratio greater than 5.8 predicted anastomotic leakage after curative surgery for colorectal cancer with 71.43% sensitivity and 73.68% specificity.
Why the study?
Anastomotic leakage is a major postoperative complication after curative colorectal cancer surgery, and early identification of patients at risk is essential to prevent associated high mortality.
Does preoperative G/L ratio predict anastomotic leakage in colorectal cancer patients undergoing curative surgery?
Cohort (n=52)
No
Does preoperative G/L ratio predict anastomotic leakage in colorectal cancer patients undergoing curative surgery?
Effect estimate: Sensitivity 71.43%, Specificity 73.68%
Preoperative granulocyte/lymphocyte ratio is a widely available and useful biomarker for identifying colorectal cancer patients at high risk for postoperative anastomotic leakage.
Differences in CRP, TNF-alpha, cortisol, and G/L ratio may flag leakage risk; leaves open predictive utility pending validation.
Abstract anastomotic leakage is one of the most important postoperative complications for colorectal cancer patients undergoing curative surgery. Early recognition of patients in risk would be essential for preventing the high mortality rates associated with these complications. C reactive protein (PCR), tumour necrosis factor (TNF-alpha), cortisol levels and granulocyte/lymphocyte ratio (G/L) were compared in this period in patients who developed leakage vs patients without this complication. Material and methods: 52 colorectal cancer patients who underwent elective surgery in a private clinical hospital were evaluated preoperatively and postoperatively for the patients. Results: 14 patients (26,9%) developed clinically significant anastomotic leakage. The best cut-off value for preoperative G/L ratio of 5,8 had sensitivity of 71,43% and specificity of 73,68%. Conclusions: Preoperative G/L ratio can be used as a largely available tool for identifying the colorectal cancer patients at high risk for anastomotic leakage.
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Bimbó-Szuhai et al. (2021) conducted a cohort in Colorectal cancer (n=52). Preoperative granulocyte/lymphocyte (G/L) ratio vs. Patients without anastomotic leakage was evaluated on Anastomotic leakage (Sensitivity 71.43%, Specificity 73.68%). A preoperative granulocyte/lymphocyte ratio greater than 5.8 predicted anastomotic leakage after curative surgery for colorectal cancer with 71.43% sensitivity and 73.68% specificity.
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