Key result
Highly elevated C-reactive protein levels at admission significantly predicted in-hospital mortality in patients with complicated intra-abdominal infections with an AUROC of 0.787.
Why the study?
The study was conducted to evaluate highly elevated C-reactive protein levels at admission as a mortality predictor in patients with complicated intra-abdominal infections.
Does highly elevated CRP at admission predict mortality in adult patients with complicated intra-abdominal infections?
Cohort (n=78)
No
Does highly elevated CRP at admission predict mortality in adult patients with complicated intra-abdominal infections?
Effect estimate: AUROC 0.787 (95% CI 0.680-0.872)
Highly elevated CRP levels (≥210 mg/L) at admission serve as a significant early predictor of in-hospital mortality in patients with complicated intra-abdominal infections, outperforming WBC and SIRS criteria.
Elevated admission CRP was associated with mortality in cIAIs; hypothesis-generating and requires prospective validation before clinical use.
PURPOSE: The aim of this study was to evaluate the highly elevated CRP levels at admission as a mortality predictor in patients with complicated intra-abdominal infections (cIAIs). METHODS: This retrospective study involved 78 adult patients with diagnosis cIAIs admitted to the Department of Surgical Diseases at a University Hospital Stara Zagora from January 2017 to October 2018. CRP concentrations, white blood cells (WBC) count, qSOFA score and SIRS criteria were determined at admission. We compared their prognostic performance using the area under receiver operating characteristics (AUROC) curves and analyzed the coordinates of the curves. RESULTS: Of the 78 enrolled patients twenty (25.6%) died during hospitalization. ROC Curve analysis revealed CRP as the best mortality predictor (AUROC = 0.787). The pairwise comparison of ROC curves showed prognostic superiority of CRP compared to WBC (AUROC = 0.787 vs. 0.511, p = 0.0194) and SIRS (AUROC = 0.787 vs. 0.579, p = 0.0315) in outcome prediction. The identified sensitivity and specificity for CRP cut-off value = 210 mg/L were 75.0% and 81.0%, respectively. CONCLUSION: We found highly elevated CRP levels at admission as a significant prognostic biomarker in patients with cIAIs.
No takes yet. Share an insight, caveat, or question.
Dimitrov et al. (2020) conducted a cohort in Complicated intra-abdominal infections (n=78). C-reactive protein (CRP) levels at admission vs. White blood cell count, SIRS, and qSOFA scores was evaluated on Mortality prediction (AUROC 0.787, 95% CI 0.680-0.872). Highly elevated C-reactive protein levels at admission significantly predicted in-hospital mortality in patients with complicated intra-abdominal infections with an AUROC of 0.787.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: