Answers are grounded in this paper and cite their sources.
We report a new acid-sensitive, biocompatible, and biodegradable microparticulate delivery system, spermine modified acetalated-dextran (Spermine-Ac-DEX), which can be used to efficiently encapsulate siRNA. These particles demonstrated efficient gene knockdown in HeLa-luc cells with minimal toxicity. This knockdown was comparable to that obtained using Lipofectamine, a commercially available transfection reagent generally limited to in vitro use due to its high toxicity.
No takes yet. Share an insight, caveat, or question.
Cohen et al. (2011) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: