Key result
Intra-arterial serotonin infusion increased upstream pulmonary vascular resistances without affecting dynamically perfused capillary surface area in rabbits.
Population
Anesthetized rabbits placed on total cardiac bypass at a constant, physiological pulmonary blood flow
Design
Preclinical
Authors
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Should not alter clinical management of pulmonary hypertension; challenges sole dependence of capillary recruitment on extracapillary factors.
The study demonstrates that pulmonary capillary recruitment may not be solely dependent on extracapillary factors, as changes in arterial resistance did not alter capillary surface area.
Fisher et al. (1998) studied this question. Intra-arterial serotonin and isoproterenol infusion was evaluated on Changes in segmental resistances and dynamically perfused capillary surface area. Intra-arterial serotonin infusion increased upstream pulmonary vascular resistances without affecting dynamically perfused capillary surface area in rabbits.
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