Why the study?
Does 5-HT infusion alter the pulmonary microvascular pressure profile in isolated dog lung lobes?
Population
19 isolated blood-perfused dog lung lobes
Comparison
5-hydroxytryptamine in saline solution vs Saline alone (10 microliter/min)
Design
Preclinical
Authors
Loading...
5-HT effects on pulmonary microvasculature remain untested in humans; leaves open its role in clinical pulmonary hypertension.
Does 5-HT infusion alter the pulmonary microvascular pressure profile in isolated dog lung lobes?
5-HT increases lung microvascular pressure by constricting both arterioles and postcapillary venules in an isolated dog lung model.
Bhattacharya et al. (1982) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: