Key result
An intravenous bolus of 5-hydroxytryptamine (100 microg) in rabbit lungs increased total pulmonary vascular resistance by 59%, causing sustained arterial and transient venous constriction.
Population
Anaesthetized (halothane 0.8%), open-chested rabbits
Comparison
Intravenous bolus infusion of 5-hydroxytryptamine vs Baseline (prior to 5HT infusion)
Design
Preclinical
Follow-up
4.8 minutes
Authors
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Caution against human extrapolation; hypothesis-generating for serotonin in pulmonary vasoconstriction, with translation to disease left open.
In a rabbit model, a 5HT bolus causes sustained arterial constriction and strong but transient venous constriction in the pulmonary microvasculature.
Sen et al. (2001) studied this question. 5-hydroxytryptamine (5HT) vs. Baseline was evaluated on Lung microvascular pressure transients. An intravenous bolus of 5-hydroxytryptamine (100 microg) in rabbit lungs increased total pulmonary vascular resistance by 59%, causing sustained arterial and transient venous constriction.
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