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Previous papers discuss the general phenomenon of succinateinduced pyridine nucleotide reduction in mitochondria (l-4) and demonstrate the energy requirement for this reaction by direct (5) and indirect(3) experimentation.The participation of succinate in energy-linked reduction of pyridine nucleotide has been examined by direct addition of succinate and by intramitochondrial formation of succinate from added cr-ketoglutarate or glutamate.Specific inhibitory responses of pyridine nucleotide reduction to malonate, phosphate, and fumarate identify succinate as the electron donor for energy-linked reduction in heart and kidney mitochondria.Other plausible explanations are also examined in some detail.
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Chance et al. (1961) studied this question.
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