Organotin compounds: from kinetics to stereochemistry and antitumour activities

An overview is given of the research performed by the authors at the Université Libre de Bruxelles and Vrije Universiteit Brussel, including the kinetics, stereochemistry and mechanism of S E 2 reactions at a saturated carbon atom, the synthesis of chiral organotin compounds and their configurational and optical stability, the fluxionality of trigonal bipyramidal metal atoms and the stereochemistry of S N 2 reactions at tetrahedrally substituted P, Si, Ge, Sn atoms, the cytotoxicity of many series of organotin compounds and the structure and reactivity of organotin salicylaldoximate clusters.