Key result
Each 10 mm Hg increase in systolic blood pressure was significantly associated with a 31% higher risk of stroke (HR 1.31), a 16% higher risk of myocardial infarction (HR 1.16), and a 10% higher risk of diabetes (HR 1.10).
Why the study?
The study was conducted to analyze age and gender differences in blood pressure associations with cardiovascular outcomes and diabetes in middle-aged and elderly Chinese adults.
Does higher blood pressure increase the risk of cardiovascular outcomes and diabetes in middle-aged and elderly Chinese adults?
Cohort (n=4,405)
Yes
Does higher blood pressure increase the risk of cardiovascular outcomes and diabetes in middle-aged and elderly Chinese adults?
Hazard Ratio: 1.31 (95% CI 1.23–1.4)
p-value: p=<0.001
Higher systolic blood pressure is strongly associated with an increased risk of stroke, myocardial infarction, and diabetes in the Chinese population, with the strongest association observed for stroke.
Age/gender modify BP-outcome links in Chinese adults; leaves open tailored thresholds pending confirmatory trials.
Objective We aim to analyze the age and gender difference in blood pressure(BP) associations with cardiovascular outcomes and diabetes in middle aged and elderly Chinese population. Method We included a total of 4,405 adults aged 40–80 years from the China Health and Nutrition Survey (CHNS) cohort. Cox proportional hazards regression models were used to estimate hazard ratios and 95% CIs. Restricted cubic spline analyses were used to explore linear and nonlinear relationships of BP with disease risk. Result With a mean follow-up of 12.2 years, 627 individuals progressed to at least one condition. Multivariable adjusted Cox models showed a strong positive association between BP and cardiovascular outcomes. Each 10 mm Hg higher usual systolic BP was significantly associated with myocardial infarction(MI)(HR[95%CI]: 1.16[1.07–1.27]), stroke(HR[95%CI]: 1.31[1.23–1.40]), and diabetes(HR[95%CI]: 1.1[1.03–1.17]). In subgroup analysis, BP was strongly associated with cardiovascular outcomes in young age group and associated with diabetes in female individuals. Conclusion BP was more strongly associated with stroke than with MI and diabetes. The strength of these associations declined with increasing age. Besides, either systolic BP or diastolic BP was more strongly associated with diabetes in female individuals than male individuals.
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Qi et al. (2022) conducted a cohort in Cardiovascular outcomes and diabetes (n=4,405). Systolic blood pressure (per 10 mm Hg increase) vs. Lower systolic blood pressure was evaluated on Incident stroke (HR 1.31, 95% CI 1.23-1.40, p=<0.001). Each 10 mm Hg increase in systolic blood pressure was significantly associated with a 31% higher risk of stroke (HR 1.31), a 16% higher risk of myocardial infarction (HR 1.16), and a 10% higher risk of diabetes (HR 1.10).
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