Efficiency of brown seaweed ( Sargassum longifolium ) polysaccharides encapsulated in nanoemulsion and nanostructured lipid carrier against colon cancer cell lines HCT 116

release kinetics of exopolysaccharides from NE (80%) and NLC (95%) was found to be slow and sustained release which indicates increase in bioavailability. The cytotoxic effect of seaweed polysaccharide, nanocarriers loaded with seaweed polysaccharide was analyzed by MTT method in colon cancer (HCT 116) cell lines with the results revealing that seaweed polysaccharide encapsulated with NLC (80%) was superior to that encapsulated with orange oil nanoemulsion (70%). This is the first report demonstrating the potential of brown seaweed exopolysaccharide encapsulated in orange oil nanoemulsion and nanostructured lipid carrier for its biomedical application.