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Forty-six patients with acute tinea pedis were treated with either 1% tolnaftate aerosol spray powder or 2% miconazole nitrate aerosol spray powder, not previously available. Products were coded, and the study was conducted in a double-blind manner. At the end of 28 days of therapy, 68% of the miconazole-treated group achieved therapeutic cure, versus 50% in the tolnaftate-treated group. Symptomatic relief and mycological clearing based on potassium hydroxide examination took place in less time for the patients treated with miconazole nitrate. The aerosol spray powder form is an effective alternative vehicle to both cream and solution.
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William V. R. Shellow (1982) studied this question.
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