Key result
Evaluation of Trypanosoma cruzi recombinant antigens with 236 serum samples identified JL7, H49, Antigen 2, and A13 as the best diagnostic reagents due to highly specific immunoreactive properties.
Why the study?
Do recombinant Trypanosoma cruzi antigens provide specific immunoreactive properties for chronic Chagas' disease diagnosis?
Observational (n=236)
Yes
Do recombinant Trypanosoma cruzi antigens provide specific immunoreactive properties for chronic Chagas' disease diagnosis?
Cloned Trypanosoma cruzi recombinant antigens, particularly JL7, H49, Antigen 2, and A13, offer highly specific immunoreactive properties for the serodiagnosis of chronic Chagas' disease.
May aid chronic Chagas serodiagnosis; hypothesis-generating pending prospective clinical validation.
A workshop organized by the Ibero-American Project of Biotechnology evaluated the diagnostic potential of several cloned Trypanosoma cruzi recombinant antigens for Chagas' disease serodiagnosis.A set of recombinants, Antigen 2, Antigen 13, SAPA, H49, A13, JL5, JL7, JL8, JL9, and RA1 provided by three different South American laboratories were probed with a panel of 236 South American serum samples.Antigens JL7, H49, Antigen 2, and A13 scored as the best diagnostic recombinant reagents.The results suggested that the main advantage of using cloned peptides for chronic Chagas' disease diagnosis resided in their highly specific immunoreactive properties.
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Mariano J. Levin (1991) conducted an observational in Chagas' disease (n=236). Trypanosoma cruzi recombinant antigens was evaluated on Diagnostic potential for Chagas' disease serodiagnosis. Evaluation of Trypanosoma cruzi recombinant antigens with 236 serum samples identified JL7, H49, Antigen 2, and A13 as the best diagnostic reagents due to highly specific immunoreactive properties.
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