Key result
Selective serotonin reuptake inhibitors (SSRIs) were associated with the development of bruising or epistaxis in five children aged 8 to 15 within 1 week to 3 months of starting treatment.
Why the study?
Do SSRIs cause bleeding side effects such as bruising or epistaxis in children and adolescents?
Case Report (n=5)
Do SSRIs cause bleeding side effects such as bruising or epistaxis in children and adolescents?
SSRIs may be associated with bleeding side effects such as bruising or epistaxis in children and adolescents, warranting further investigation.
Answers are grounded in this paper and cite their sources.
May warrant bleeding monitoring in pediatric SSRI initiations; leaves open causality pending controlled studies.
The selective serotonin reuptake inhibitors (SSRIs) are becoming widely used in children and adolescents, with possible unexpected side effects being observed over time. SSRIs have been associated with bleeding in adults who have unremarkable routine hematologic laboratory results except abnormal bleeding time or platelet counts in few cases. Given the increase of pediatric SSRI prescriptions, in this article we describe five children, ages 8 through 15, who developed bruising or epistaxis 1 week to 3 months after starting SSRI treatment. It is possible that the effects SSRI on platelet functioning are causing the bleeding observed in some patients and/or that a separate coagulopathy is present and contributing to bleeding. The subject matter deserves future investigation.
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LAKE et al. (2000) conducted a case report in Bruising or epistaxis (n=5). Selective Serotonin Reuptake Inhibitors (SSRIs) was evaluated on Bruising or epistaxis. Selective serotonin reuptake inhibitors (SSRIs) were associated with the development of bruising or epistaxis in five children aged 8 to 15 within 1 week to 3 months of starting treatment.
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