Key result
Compared with beta-blocker users, calcium channel blocker use in hypertensive patients was associated with an increased risk of gastrointestinal tract bleeding (adjusted RR 2.05; 95% CI 1.33-3.17).
Why the study?
Does calcium channel blocker use increase the risk of hospitalized gastrointestinal tract bleeding compared to beta-blocker use in hypertensive patients?
Population
945 treated hypertensive members of a health maintenance organization
Comparison
Calcium channel blocker use vs Beta-blocker use
Design
Case-control
Authors
Loading...
May signal elevated GI bleeding risk with calcium channel blockers; hypothesis-generating and should not yet change practice.
Case-Control (n=945)
Does calcium channel blocker use increase the risk of hospitalized gastrointestinal tract bleeding compared to beta-blocker use in hypertensive patients?
Relative Risk: 2.05 (95% CI 1.33–3.17)
Calcium channel blocker use in hypertensive patients may be associated with an elevated risk of hospitalized gastrointestinal bleeding compared to beta-blocker use.
Kaplan et al. (2000) conducted a case-control in Hypertension and Gastrointestinal Tract Bleeding (n=945). Calcium channel blockers vs. Beta-blockers was evaluated on Gastrointestinal tract bleeding (RR 2.05, 95% CI 1.33-3.17). Compared with beta-blocker users, calcium channel blocker use in hypertensive patients was associated with an increased risk of gastrointestinal tract bleeding (adjusted RR 2.05; 95% CI 1.33-3.17).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: