Why the study?
There is limited understanding of how neural activity is modified during decision-making in youth with major depressive disorder who have attempted suicide.
Are neural responses during decision-making altered in youth with major depressive disorder and past suicide attempts compared to those without attempts and healthy controls?
Population
79 individuals aged 16-25 with MDD (39 suicide attempters, 40 non-attempters) and 40 matched healthy controls
Comparison
MDD suicide attempters vs MDD non-attempters vs healthy controls
Key result
Youth with major depressive disorder and past suicide attempts exhibited the poorest decision-making performance and blunted ΔFN compared to those without attempts and healthy controls.
Authors
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Blunted ΔFN during decision-making in depressed youth with suicide attempts is hypothesis-generating; leaves open EEG markers for risk stratification.
Cross-Sectional (n=119)
Are neural responses during decision-making altered in youth with major depressive disorder and past suicide attempts compared to those without attempts and healthy controls?
Youth with MDD and past suicide attempts exhibit specific neural deficits in decision-making, characterized by blunted feedback evaluation and altered sensitivity to gains and losses.
Bao et al. (2024) conducted a cross-sectional in Major depressive disorder with and without past suicide attempts (n=119). Past suicide attempts vs. Major depressive disorder without suicide attempts and healthy controls was evaluated on Feedback processing measured by feedback-related negativity (FRN), ΔFN, and P300 during the Iowa Gambling Task. Youth with major depressive disorder and past suicide attempts exhibited the poorest decision-making performance and blunted ΔFN compared to those without attempts and healthy controls.
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