Why the study?
Does prophylactic infusion of ephedrine plus phenylephrine reduce maternal hypotension compared to ephedrine alone in parturients undergoing caesarean section under spinal anaesthesia?
Population
60 parturients with ASA grade I-II scheduled for caesarean section under spinal anaesthesia
Comparison
Prophylactic IV infusion of Ephedrine 2mg/min in… vs Prophylactic IV infusion of Ephedrine 2mg/min…
Design
RCT, randomized, double blind
Key result
Prophylactic infusion of ephedrine plus phenylephrine significantly reduced the incidence of maternal hypotension compared to ephedrine alone (10% vs 33.66%, p=0.015) during caesarean section.
Authors
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Combination infusion reduces maternal hypotension versus ephedrine alone in spinal caesarean; supports protocol adoption and further outcome trials.
RCT (n=60)
Double-blind
Randomized
No
Does prophylactic infusion of ephedrine plus phenylephrine reduce maternal hypotension compared to ephedrine alone in parturients undergoing caesarean section under spinal anaesthesia?
Absolute Event Rate: 10% vs 33.66%
p-value: p=0.015
Adding phenylephrine to prophylactic ephedrine infusion significantly reduces the incidence of maternal hypotension, nausea, and vomiting during caesarean section under spinal anaesthesia.
Lokesh et al. (2014) conducted an RCT in Hypotension during caesarean section under spinal anaesthesia (n=60). Ephedrine plus Phenylephrine infusion vs. Ephedrine alone infusion (2mg/min) was evaluated on Incidence of hypotension (systolic blood pressure <100mmHg or <80% of baseline before delivery) (p=0.015). Prophylactic infusion of ephedrine plus phenylephrine significantly reduced the incidence of maternal hypotension compared to ephedrine alone (10% vs 33.66%, p=0.015) during caesarean section.
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