Key result
High-flux hemodialysis significantly decreased NT-proBNP, BNP, and TnT levels (P≤0.01 for all), whereas low-flux hemodialysis increased NT-proBNP and TnT levels (P≤0.001).
Why the study?
Does hemodialysis with a high-flux membrane compared to a low-flux membrane affect plasma levels of cardiac biomarkers in hemodialysis patients?
Population
31 hemodialysis patients
Comparison
Hemodialysis with high-flux (HF) membrane vs Hemodialysis with low-flux membrane
Design
RCT, Randomized to start dialysis with a LF-HD or HF-HD dialyzer in a…
Follow-up
Two consecutive weeks (one treatment per week)
Authors
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High-flux hemodialysis may mask acute cardiac events by lowering biomarkers; extends evidence on membrane flux effects in dialysis patients.
RCT (n=31)
Crossover
Does hemodialysis with a high-flux membrane compared to a low-flux membrane affect plasma levels of cardiac biomarkers in hemodialysis patients?
p-value: p=≤0.01
High-flux hemodialysis significantly reduces plasma levels of cardiac biomarkers (BNP, NT-proBNP, TnT), which could potentially mask acute cardiac events like myocardial infarction.
Laveborn et al. (2015) conducted an RCT in Hemodialysis (n=31). High-flux (HF) hemodialysis vs. Low-flux (LF) hemodialysis was evaluated on Plasma levels of BNP, NT-proBNP, and TnT (p=≤0.01). High-flux hemodialysis significantly decreased NT-proBNP, BNP, and TnT levels (P≤0.01 for all), whereas low-flux hemodialysis increased NT-proBNP and TnT levels (P≤0.001).
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