Synthetic study demonstrates cobalt(II)-catalyzed [4+2] annulation of picolinamides with alkynes, indicating an efficient, oxidant-free pathway to functionalized benzoquinolines.
A cobalt(II)-catalyzed [4+2] annulation of picolinamides with alkynes via C-H bond activation has been developed. The operationally simple annulation reaction allows for the synthesis of acyl-substituted 1H-benzoquinoline bearing multiple aromatic rings (up to 96 % yield) without co-oxidant or other oxidation factors under mild conditions. Several control experiments were carried out. This practical [4+2] annulation provides an efficient route to access highly functionalized compounds.
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Yao et al. (2020) studied this question.
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