Cobalt-Catalyzed Regioselective (4+2)-Annulation of Benzamides with Allenyl Carbinol Acetates: Access to 3-Vinylisoquinolinones

Q: What type of study is this?

This is a Experimental Study study.

Chandra M. R. Volla; Pravin Kumar; Om Prakash Dash

doi:10.1039/d5cc04210k

January 1, 2025Chemical Communications

Cobalt-Catalyzed Regioselective (4+2)-Annulation of Benzamides with Allenyl Carbinol Acetates: Access to 3-Vinylisoquinolinones

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Key Points

The cobalt-catalyzed reaction provides high yields of various heterocyclic derivatives, showcasing utility.
Regioselectivity is a key feature, with excellent outcomes facilitating the synthesis of 3-vinylisoquinolinones.
The methodology involves the reaction of benzamides with allenyl carbinol acetates under specific conditions.
Success highlights potential applications in synthesizing complex organic molecules in medicinal chemistry.

Implication

Co-catalyzed (4+2)-annulation achieves high yields in benzamide reactions, suggesting novel heterocyclic derivatives.

Abstract

Herein we disclose a Co-catalyzed regioselective (4+2)annulation of aryl-, heteroaryl-and acrylamides with allenyl acetates to access a diverse array of heterocyclic derivatives in high yields with excellent regioselectivity. The protocol...

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Cite This Study

Volla et al. (2025) studied this question.

synapsesocial.com/papers/68d462db31b076d99fa629ea https://doi.org/10.1039/d5cc04210k

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Cobalt-Catalyzed Regioselective (4+2)-Annulation of Benzamides with Allenyl Carbinol Acetates: Access to 3-Vinylisoquinolinones

Key Points

Implication

Abstract

Discussion

Cite This Study

Cobalt-Catalyzed Regioselective (4+2)-Annulation of Benzamides with Allenyl Carbinol Acetates: Access to 3-Vinylisoquinolinones

Key Points

Implication

Abstract

Discussion

Cite This Study

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