Key result
Serum NGAL and cystatin C levels diagnosed early renal dysfunction in older patients with coronary artery disease with areas under the curve of 0.884 and 0.744, respectively.
Why the study?
Are serum NGAL and cystatin C accurate diagnostic markers for early renal dysfunction in older patients with coronary artery disease?
Observational (n=84)
Are serum NGAL and cystatin C accurate diagnostic markers for early renal dysfunction in older patients with coronary artery disease?
Serum NGAL and cystatin C demonstrate good diagnostic accuracy for early renal dysfunction in older patients with coronary artery disease.
Supports evaluation of serum NGAL for early renal dysfunction in older CAD patients; leaves open prospective validation before clinical adoption.
Objective This study aimed to assess the diagnostic value of serum neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C for renal dysfunction in older patients with coronary disease. Methods A total of 84 older patients with coronary artery disease were included in this study. Serum NGAL and cystatin C levels were analysed using commercially available kits. Medical data of all patients were recorded and analysed. Results NGAL and cystatin C levels were significantly positively correlated with N-terminal prohormone of brain natriuretic peptide levels and negatively correlated with the estimated glomerular filtration rate. The areas under the receiver operating characteristic curves of serum NGAL and cystatin C levels for diagnosing early renal dysfunction were 0.884 and 0.744, respectively. Conclusion Serum NGAL and cystatin C are potential early and sensitive markers of renal dysfunction in older patients with coronary artery disease.
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Zhu et al. (2018) conducted an observational in Coronary artery disease (n=84). Serum NGAL and cystatin C was evaluated on Diagnosis of early renal dysfunction (AUC 0.884 for NGAL and 0.744 for cystatin C). Serum NGAL and cystatin C levels diagnosed early renal dysfunction in older patients with coronary artery disease with areas under the curve of 0.884 and 0.744, respectively.
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