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Cellular proliferation of both epidermal and mesenchymal cells of denerved cone stage limb blastemas (Pleurodeles waltlii Michah) was studied in vivo. The mitotic index and thymidine 3H incorporation (autoradiography following short term (1 hr) incubation and scintigraphy) show that denervation causes a significant decrease in the cellular proliferation (about 70% 4 days after denervation). Denervation affects first the mesenchymal cells, the proliferation of epidermal cells declines later. These results are discussed in term of cellular cycle.
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Boilly et al. (1985) studied this question.
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