What question did this study set out to answer?

To determine whether sensory neural feedback from contracting limb muscles is essential for exercise hyperpnea and steady-state gas exchange.

May 1, 1979Journal of Applied Physiology

Ventilation and gas exchange during phasic hindlimb exercise in the dog

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Authors

MWM. L. WeissmanUniversity of California, Los Angeles KWKarlman WassermanCross-Cutting Cardiology DHD. J. HuntsmanUCLA Medical Center

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Implication

Neural afferents from contracting muscles are not obligatory for steady-state isocapnic hyperpnea in dogs; leaves open their role in human exercise ventilation.

Key Points

To determine whether sensory neural feedback from contracting limb muscles is essential for exercise hyperpnea and steady-state gas exchange.
Induced rhythmic hindlimb muscle contractions in dogs for 4- to 5-minute periods by electrically stimulating the peripheral cut ends of the sciatic and femoral nerves bilaterally.
Measured breath-by-breath minute ventilation (VE), carbon dioxide output (VCO2), and oxygen uptake (VO2), while monitoring arterial PCO2 (PaCO2) continuously via an indwelling electrode.
Steady-state VO2 and VCO2 approximately doubled during stimulation, rising with half-times (t1/2) of 25 +/- 2 s and 35 +/- 4 s, respectively.
Ventilation (VE) increased within five breaths of stimulation onset and approached steady state with a t1/2 of 37 +/- 5 s.
Mean PaCO2 showed a transient increase within the first minute of exercise but returned to levels not significantly different from control during the steady state.

Cite This Study

Weissman et al. (1979) studied this question.

synapsesocial.com/papers/6a9650d7dbc641e6a0a6b3e9 https://doi.org/10.1152/jappl.1979.46.5.878

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Implication

Neural afferents from contracting muscles are not obligatory for steady-state isocapnic hyperpnea in dogs; leaves open their role in human exercise ventilation.

Ventilation and gas exchange during phasic hindlimb exercise in the dog

Discussion

Member takes

Implication

Key Points

Cite This Study

Ventilation and gas exchange during phasic hindlimb exercise in the dog

Discussion

Member takes

Implication

Key Points

Cite This Study

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