July 1, 1955Circulation ResearchOpen Access

The Acute Effects of Elimination of the Moderator Reflexes Upon Cardiac Output and Total Peripheral Resistance in the Anesthetized Dog

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Population

Anesthetized dogs

Design

Preclinical

Follow-up

acute

Authors

MLMatthew N. LevyTechnion – Israel Institute of Technology SBShirley H. BrindAlbany Medical Center Hospital FBFREDERICK R. BRANDLINAlbany Medical Center Hospital

Discussion

Member takes

Implication

Animal data link moderator reflex loss to vasoconstriction-driven hypertension; leaves open human relevance.

Structured PICO

Population

Anesthetized dogs

Intervention

Elimination of the moderator reflexes (denervation)

Outcome

Mean arterial pressure, cardiac output, and total peripheral resistancesurrogate

In anesthetized dogs, acute hypertension following elimination of moderator reflexes is driven by severe generalized vasoconstriction rather than increased cardiac output.

Cite This Study

Levy et al. (1955) studied this question.

synapsesocial.com/papers/6a9652dd3bc4f0b8d469c9dc https://doi.org/10.1161/01.res.3.4.415

Topics

Hypertension management

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The Acute Effects of Elimination of the Moderator Reflexes Upon Cardiac Output and Total Peripheral Resistance in the Anesthetized Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The Acute Effects of Elimination of the Moderator Reflexes Upon Cardiac Output and Total Peripheral Resistance in the Anesthetized Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider