What question did this study set out to answer?

To evaluate the relationships among perceived stress, depressive symptoms, plasma cortisol, and inflammatory cytokines during the second trimester of pregnancy.

September 16, 2014Biological Research For Nursing

Relationships Among Prenatal Depression, Plasma Cortisol, and Inflammatory Cytokines

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Authors

MSMelissa M. SheltonUniversity of South Florida DSDonna SchminkeyJames Madison University MGMaureen GroërSpringer Nature (Germany)

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Implication

Observational pilot study uncovers inverse links between depressive symptoms, cortisol, and cytokines in pregnant women, suggesting tight immune regulation during gestation.

Key Points

To evaluate the relationships among perceived stress, depressive symptoms, plasma cortisol, and inflammatory cytokines during the second trimester of pregnancy.
Secondary pilot analysis of N = 105 pregnant women at 16 to 26 weeks' gestation, selected from a larger parent cohort (N = 631).
Assessed psychological stress via Cohen's Perceived Stress Scale and depressive symptoms via the Profile of Mood States Depression/Dejection Scale.
Measured plasma cortisol using an enzyme-linked immunosorbent assay (ELISA) and 12 cytokines using a multiplex bead array.
Perceived stress and depressive symptoms were strongly and positively correlated.
Depressive symptoms correlated inversely with three cytokines: interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-7.
Plasma cortisol correlated inversely with proinflammatory cytokines (IL-1β, TNF-α) as well as anti-inflammatory cytokines (IL-4, IL-5, IL-10, IL-13).

Cite This Study

Shelton et al. (2014) studied this question.

synapsesocial.com/papers/6a96557cda4ae31144f69727 https://doi.org/10.1177/1099800414543821

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Implication

Observational pilot study uncovers inverse links between depressive symptoms, cortisol, and cytokines in pregnant women, suggesting tight immune regulation during gestation.

Relationships Among Prenatal Depression, Plasma Cortisol, and Inflammatory Cytokines

Discussion

Member takes

Implication

Key Points

Cite This Study

Relationships Among Prenatal Depression, Plasma Cortisol, and Inflammatory Cytokines

Discussion

Member takes

Implication

Key Points

Cite This Study

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