Key result
Cotransfection of HCN4 with constitutively activated Src protein (Src529) positively shifted voltage-dependent HCN4 activation (V1/2 = -80 mV vs -93 mV for HCN4 alone).
Absolute Event Rate: -80% vs -93%
Src tyrosine kinase modulates the cardiac pacemaker current (if) by directly binding to and altering the gating of HCN4 channels.
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Src-HCN4 gating shift is preclinical only; hypothesis-generating for If regulation in intact pacemakers.
Arinsburg et al. (2006) studied this question. Cotransfection with constitutively activated Src protein (Src529) vs. HCN4 alone was evaluated on Voltage-dependent HCN4 activation (V1/2). Cotransfection of HCN4 with constitutively activated Src protein (Src529) positively shifted voltage-dependent HCN4 activation (V1/2 = -80 mV vs -93 mV for HCN4 alone).
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