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January 1, 2008Thrombosis and Haemostasis

Do we need thrombin generation assays for monitoring anticoagulation?

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MBMartin BorggrefeElectrophysiologyCDCarl‐Erik DempfleDemos

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Borggrefe et al. (2008) studied this question.

synapsesocial.com/papers/6a9658cb672df19136a6b3f4https://doi.org/10.1160/th08-07-0437
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ability of Recombinant Factor VIIa to Reverse the Anticoagulant Effect of the Pentasaccharide Fondaparinux in Healthy Volunteers2002 · 322 citations
  2. 2The Pharmacokinetics of Enoxaparin Do Not Correlate With Its Pharmacodynamic Effect in Patients Receiving Dialysis Therapies2006 · 37 citations
  3. 3Thrombin generation assays are superior to traditional tests in assessing anticoagulation reversal in vitro2008 · 88 citations
  4. 4Poor reversal of low molecular weight heparin by protamine2000 · 45 citations
  5. 5Recombinant activated factor VII effectively reverses the anticoagulant effects of heparin, enoxaparin, fondaparinux, argatroban, and bivalirudin ex vivo as measured using thromboelastography2007 · 105 citations