Key result
The chromosome 9p21 risk allele is associated with a 20% to 30% increased risk of CAD and MI per copy, an effect unaltered by adjustment for traditional cardiovascular risk factors.
Why the study?
Does the chromosome 9p21 risk allele increase the risk of CAD and MI?
Does the chromosome 9p21 risk allele increase the risk of CAD and MI?
Effect estimate: 20% to 30% increased risk per copy
The chromosome 9p21 locus represents a major genetic risk factor for CAD and MI, independent of traditional risk factors.
May inform polygenic CAD/MI risk scores; leaves open whether 9p21 testing improves outcomes beyond traditional factors.
T he middle of 2007 saw what may, with time, turn out to be the single most important discovery in the genetics of cardiovascular diseases. ] The risk allele as currently defined, until causal variants are identified, is common (allele frequency of almost 50%) and associated with a 20% to 30% increased risk per copy. The effect of the 9p21 locus on CAD and MI risk is unaltered by adjustment for traditional cardiovascular risk factors
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Heribert Schunkert (2008) conducted a review in Cardiovascular diseases (CAD and MI). Chromosome 9p21 risk allele was evaluated on CAD and MI risk (20% to 30% increased risk per copy). The chromosome 9p21 risk allele is associated with a 20% to 30% increased risk of CAD and MI per copy, an effect unaltered by adjustment for traditional cardiovascular risk factors.
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