Key result
Covalent heparin modification of a polysulfone flat sheet membrane demonstrated good blood compatibility and excellent selective affinity for LDL in single and binary protein solutions.
Heparin-modified polysulfone membranes demonstrate selective LDL affinity and good blood compatibility, suggesting potential utility for simultaneous hemodialysis and LDL apheresis.
May support dual-function dialysis membranes for LDL removal; hypothesis-generating and requires clinical validation before any practice consideration.
A simple, convenient and economical method for the heparinization of PSf membranes is described, with the aim of preparing an LDL adsorber for simultaneous LDL apheresis and hemodialysis. An atmospheric pressure glow discharge generator is used to activate the PSf membrane surface, with subsequent chemical binding of heparin in the presence of EDC and NHS. ATR-FTIR spectroscopy and XPS measurements confirm successful surface modification. The PSf-Hep membrane shows good blood compatibility, with a relatively low amount and normal morphology of adherent platelets. ELISA results indicate that the PSf-Hep membrane exhibits excellent selective affinity for LDL in single and binary protein solutions, suggesting potential applications in hemodialysis with simultaneous LDL removal.
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Li et al. (2011) studied this question. Heparinization of polysulfone (PSf) membranes was evaluated on Surface modification, blood compatibility, and selective affinity for LDL. Covalent heparin modification of a polysulfone flat sheet membrane demonstrated good blood compatibility and excellent selective affinity for LDL in single and binary protein solutions.
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