Key result
A UV spectrophotometric method was developed and validated for estimating amlodipine, demonstrating 99.80% accuracy for the pure compound and 99.20% for marketed tablet formulations.
A simple, accurate UV spectrophotometric method was developed and validated for estimating amlodipine in bulk and tablet formulations.
Validated UV method quantifies amlodipine accurately; leaves open routine adoption pending independent clinical validation.
In the present work an inexpensive, easy, mercurial, particular, sensible and reproducible and spectrophotometric method has been developed and validated for the estimation of amlodipine in pure drug and Marketed Tablet Formulation. Analysis was carried out at 338nm for pure drug amlodipine and 355nm for amlodipine marketed tablet formulation. The main purpose of the investigation was to measure that how much percentage of drug present in marketed tablet formulation for the estimation of amlodipine besylate tablet and amlodipine pure drug using methanol as a solvent, a simple method has been developed. The accuracy of the method was assessed by dues studies and was found to be in spectrum of 99.80% of amlodipine pure compound and 99.20% of amlodipine marketed tablet formulation. The LOD were found 0.132 and 0.141µg/ml of amlodipine pure drug and LOQ were 0.416 and 0.427µg/ml of marketed tablet respectively. The result were validated found to be fair and met the admissible criteria.
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Chanchal Deep Kaur (2017) studied this question. Ultra-violet spectrophotometric method was evaluated on Accuracy of amlodipine estimation in pure drug and marketed tablet formulation. A UV spectrophotometric method was developed and validated for estimating amlodipine, demonstrating 99.80% accuracy for the pure compound and 99.20% for marketed tablet formulations.
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