Key result
Serum magnesium level had a significant inverse correlation with common carotid intima-media thickness (P=0.045) and ischemic heart disease (P=0.012) in hemodialysis patients.
Why the study?
Serum magnesium has a role in cardiovascular complications in dialysis patients, but its correlation with atherosclerotic changes in maintenance hemodialysis patients required investigation.
Cohort (n=60)
p-value: p=0.045
Serum magnesium levels have a significant inverse correlation with carotid intima-media thickness and ischemic heart disease in hemodialysis patients, though age and diabetes are stronger independent predictors.
Low serum magnesium was associated with greater carotid IMT and IHD in hemodialysis patients; leaves open whether repletion modifies cardiovascular outcomes.
Background: Cardiovascular complications in dialysis patients focused on atherosclerosis. Serum magnesium has a role in cardiovascular complications in dialysis patients. Objectives: This study aimed to study the correlation between serum magnesium level and atherosclerotic changes in patients on maintenance hemodialysis. Patients and methods: This prospective study included 60 patients with end-stage renal disease patients on maintenance HD, divided into Group I: (20 patients) with normal serum magnesium level (1.7 -2.8 mg/dl), Group II (20 patients) with low serum magnesium level (< 1.7mg/dl) and Group III (20 patients) with high serum magnesium level (> 2.8mg/dl.). Serum magnesium and lipid profile and intima-media thickness (IMT) of both common carotid arteries were measured. Results: Our results showed a significant negative association between level of serum Mg and IMT complex of both common carotid (P = 0.045) and ischemic heart disease in the studied patients (P = 0.012). The binary logistic regression for the predictors for IHD and CCA-IMT, we found that serum magnesium not an independent factor for atherosclerosis but we found that age and DM (P ˂ 0.001) followed by cholesterol and triglycerides (P ˂ 0.05) are the most independent factors for CCA-IMT. Also, age (with OR: 95% confidence Interval) (0.145:1.26-1.06) (P ˂ 0.001) and triglycerides (1.02:1.05-1.002), (P ˂ 0.05) are the independent factors for IHD. Conclusion: Our study revealed a significant inverse correlation between level of serum Mg and CCA-IMT and IHD in the studied HD patients. Thus, we suggest that regular screening of HD patients for serum Mg and CIMT with special consideration to diabetic and old patients is recommended to stratify their CV risk.
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Alarbagy et al. (2020) conducted a cohort in End-stage renal disease on maintenance hemodialysis (n=60). Serum magnesium level vs. Normal serum magnesium level (1.7-2.8 mg/dl) was evaluated on Intima-media thickness (IMT) of both common carotid arteries and ischemic heart disease (p=0.045). Serum magnesium level had a significant inverse correlation with common carotid intima-media thickness (P=0.045) and ischemic heart disease (P=0.012) in hemodialysis patients.
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