Normal and Altered Function of the Renin-Angiotensin-Aldosterone System in Man

Article1 August 1965Normal and Altered Function of the Renin-Angiotensin-Aldosterone System in ManApplications in Clinical and Research MedicineJEROME W. CONN, M.D., SC.D., F.A.C.P., DAVID R. ROVNER, M.D., EDWIN L. COHEN, M.D.JEROME W. CONN, M.D., SC.D., F.A.C.P., DAVID R. ROVNER, M.D., EDWIN L. COHEN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-2-266 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI am pleased to be able to present the 1965 John Phillips Memorial Lecture for several reasons. First, I am happy to be participating in the memorialization of an eminent American physician who was a Regent of the College at the time of his tragic death in 1929. Second, I am fully cognizant of the honor that accompanies the designation of the Phillips Memorial Lecturer, and I am proud to be listed with the 28 former recipients. And, third, I am pleased to be called upon to do my job at this special Golden Anniversary Session of the College.I...References1. CONN JW: In discussion of paper "The Functions for Renin and Angiotensin" by W. S. PEART at Laurentian Hormone Conference, September 8 1964, Lake George, N.Y., in Recent Progress in Hormone Research, Academic Press, New York and London. In press. Google Scholar2. CONNCOHENROVNER JWELDR: Suppression of plasma renin activity in primary aldosteronism. Distinguishing primary from secondary aldosteronism in hypertensive disease. JAMA 190: 213, 1964. CrossrefMedlineGoogle Scholar3. CONN JW: Plasma renin activity in primary aldosteronism. Importance in differential diagnosis and in research of essential hypertension. Ibid., p. 222. Google Scholar4. MULROWGANONG PJWF: The effect of hemorrhage upon aldosterone secretion in normal and hypophysectomized dogs. J. Clin. Invest. 40: 579, 1961. CrossrefMedlineGoogle Scholar5. TOBIAN L: Sodium, renal arterial distension and juxtaglomerular apparatus. Canad. Med. Ass. J. 90: 160, 1964. MedlineGoogle Scholar6. VANDERMILLER AJR: Control of renin secretion in the anesthetized dog. Amer. J. Physiol. 207: 537, 1964. CrossrefMedlineGoogle Scholar7. ROVNERCONNKNOPFCOHENHSUEH DRJWRFELMT: The nature of renal escape from the sodium-retaining effect of aldosterone in primary aldosteronism and in normal subjects. J. Clin. Endocr. 25: 33, 1965. CrossrefGoogle Scholar8. COHENROVNERCONNBLOUGH ELDRJWWM: Effects of position, exercise, and sodium intake on plasma renin activity in normal people. Clin. Res. 12: 362, 1964. Google Scholar9. COHENROVNERCONN ELDRJR: To be published. Google Scholar10. TAITTAITUNDERWOOD JFSAR: Dynamic aspects of metabolism of aldosterone, in Symposium on Aldosterone, Council for International Organization of Medicine Science, Prague, 1964. To be published. Google Scholar11. CONN JW: Primary aldosteronism: a new clinical syndrome. J. Lab. Clin. Med. 45: 6, 1955. Google Scholar12. VEYRATDE CHAMPLAINBOUCHERGENEST RJRJ: Measurement of human arterial renin activity in some physiological and pathological states. Canad. Med. Ass. J. 90: 215, 1964. MedlineGoogle Scholar13. CONN JW: Overproduction of aldosterone, hyperaldosteronuria, hyperaldosteronemia, and aldosteronism, primary and secondary (Critical Comments). JAMA. To be published. Google Scholar14. ROVNERCOHENCONNREYES-LEAL DRELJWB: Aldosterone, renin activity and sodium kinetics in idiopathic edema. Submitted to The Endocrine Society, 1965. Google Scholar15. CONNKNOPFNESBIT JWRFRM: The clinical characteristics of primary aldosteronism from an analysis of 145 cases. Amer. J. Surg. 107: 159-172, 1964. CrossrefMedlineGoogle Scholar16. CONNCONN JWES: Primary aldosteronism versus hypertensive disease with secondary aldosteronism. Recent Prog. Horme Res. 17: 389, 1961. MedlineGoogle Scholar17. GENEST J:Angiotensin, aldosterone, and human arterial hypertension. Canad. Med. Ass. J. 84: 403, 1961. MedlineGoogle Scholar18. LARAGH JH: Interrelations between angiotensin, norepinephrine, epinephrine, aldosterone secretion, and electrolyte metabolism in man. Circulation 25: 203, 1962. CrossrefMedlineGoogle Scholar19. LARAGHULICKJANUSZEWICZLIEBERMANDEMINGKELLY JHSVSQBWG: Aldosterone secretion and primary and malignant hypertension. J. Clin. Invest. 39: 1091, 1960. CrossrefMedlineGoogle Scholar20. LAIDLAWRUSEKILLINGERYENDTGORNALL JCJLDWERAG: Hypertension and renal loss of potassium. Trans. Amer. Clin. Climat. Ass. 73: 99, 1961. MedlineGoogle Scholar21. HELMER OM: Renin activity in blood from patients with hypertension, in Proceedings International Symposium on Angiotensin, Sodium and Hypertension, Quebec, 1963, p. 221. Google Scholar22. MORRISROBINSONSCHEELE REPRGA: The relationship of angiotension to renal hypertension. Ibid., p. 272. Google Scholar23. KAPLAN NM: Primary aldosteronism with malignant hypertension. New England J. Med. 269: 1282, 1963. CrossrefMedlineGoogle Scholar24. CONNKNOPFNESBIT JWRFRM: Primary aldosteronism. Present evaluation of its clinical characteristics and of the results of surgery, in International Conference on Aldosteronism, Council for International Organization of Medical Science, Prague, 1963, p. 339. Google Scholar25. BIGLIERIFORSHAM EGPJ: Studies on expanded extracellular fluid and responses to various stimuli in primary aldosteronism. Amer. J. Med 30: 564, 1961. CrossrefGoogle Scholar26. DUNIHUEROBERTSON FWWV: Effect of desoxycorticosterone acetate and of sodium on juxtaglomerular apparatus. Endocrinology 61: 293, 1957. CrossrefMedlineGoogle Scholar27. CONN JW, Unpublished observations. Google Scholar28. BOUCHERVEYRATDE CHAMPLAIN RRJ: New procedures for measurement of human plasma angiotensin and renin activity levels. Canad. Med. Ass. J. 90: 194, 1964. MedlineGoogle Scholar29. COHENROVNERCONN ELDRJW: to be published. Google Scholar30. BARTTERPRONOVEGILLMACCARDLE FCPJRRC: Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis: a new syndrome. Amer. J. Med. 33: 11, 1962. CrossrefGoogle Scholar31. GARSTSHUMWAYSCHWARTZFARRELL JBNPHGL: Aldosterone excretion in essential hypertension. J. Clin. Endocr. 20: 1351, 1960. CrossrefGoogle Scholar32. BROWNDAVIESLEVERROBERTSON JJDLAFJI: Variations in plasma renin concentration in several physiological and pathological states. Canad. Med. Ass. J. 90: 201, 1964. MedlineGoogle Scholar33. SHAMMAGODDARDSOMMERS AHJWSC: Study of adrenal status in hypertension. J. Chronic Dis. 8: 587, 1958. CrossrefMedlineGoogle Scholar34. SHERWIN R: Present status of pathology of adrenal gland in hypertension, Amer. J. Surg. 107: 136, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, MichiganFrom the Department of Internal Medicine, Division of Endocrinology and Metabolism and the Metabolic Research Unit, University of Michigan, Ann Arbor, Mich.Work from the authors' laboratory to which reference is made has been supported by the U. S. Army Medical Research and Development Command Grant DA-MD-49-193-62-G62, grants 5-K6-AM-14, 237 and TI AM 5001 from the U. S. Public Health Service, Bethesda, Md., and grant 5MO1-FR-4204 from the Division of Research Facilities and Resources, U. S. Public Health Service, Bethesda, Md.This paper was presented as the 1965 John Phillips Memorial Award Lecture at the Golden Anniversary Session of the American College of Physicians in Chicago, Ill., March 22, 1965.Requests for reprints should be addressed to Jerome W. Conn, M.D., Division of Endocrinology and Metabolism and the Metabolic Research Unit, University Hospital, the University of Michigan Medical Center, Ann Arbor, Mich. 48104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Expanding Spectrum of Primary Aldosteronism: Implications for Diagnosis, Pathogenesis, and TreatmentNormotension, hypertension and body fluid regulation: brain and kidneyPersistent Hyperkalemia Status Postadrenalectomy for Primary AldosteronismFunctional genetic variation in aminopeptidase A (ENPEP): Lack of clear association with focal and segmental glomerulosclerosis (FSGS)A Case Of Transient Hyporeninemic Hypoaldosteronism After Unilateral Adrenalrectomy for Aldosterone-Producing AdenomaPrimary hyperaldosteronism in childhood due to unilateral macronodular hyperplasia. 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RICHARD CROUT, M.D., F.A.C.P., NORMAN M. KAPLAN, M.D., F.A.C.P.Adrenalectomy in Cases of Severe Renal SclerosisPrimary Aldosteronism: Diagnosis and TreatmentCo-Existing Aldosterone-Producing Adrenal Tumor (Aldosteronema) and Bilateral Renovascular LesionsRegulation der Reninsekretion beim Bartter-SyndromZur Pathogenese der sogenannten malignen HypertonieCase 33-1968Incidence of Suppressed Renin Activity and of Normokalemic Primary Aldosteronism in Hypertensive Negro PatientsMETABOLIC AND HORMONAL STUDIES IN A PATIENT WITH PRIMARY ALDOSTERONISM, PRESENTING WITH ACUTE HYPOKALAEMIC PARESIS INDUCED BY CHLOROTHIAZIDERenin-Angiotensin-Aldosteronsystem bei Störungen der BlutdruckregulationRegulation der Reninsekretion beim NatriummangelPhysiologie und Pathologie des Renin/Angiotensin-SystemsRenale Mastocytose und sekund�rer AldosteronismusPlasma renin activity in hypertensionHYPERTENSION: ITS MANAGEMENT AND INVESTIGATIONRENAL PRESSOR MECHANISMSPrimary Aldosteronism: Its Diagnosis and Surgical ManagementDigital Vascular Response to Angiotensin II in Normotensive and Hypertensive SubjectsThe Diagnosis Essential HypertensionStudies on the histochemistry of phosphatase enzymes in the juxtaglomerular complexSodium Ion in Drinking Water . II. Importance, Problems, and Potential Applications of Sodium-Ion-Restricted TherapyPossibility of normokalaemic primary aldosteronism as reflected in the frequency of adrenal cortical adenomasThe Angiotensin Infusion TestGlucocorticoid suppression from aldosteronomasRenal Function During and After SurgeryRenin-Angiotensin-System und Pathogenese des renalen HochdruckesThe activity of the renin-angiotensin-aldosterone system in hypertensive and hydropic diseasesHypertension, the Potassium Ion and Impaired Carbohydrate Tolerance 1 August 1965Volume 63, Issue 2Page: 266-284KeywordsAdenomasEndocrinologyHealth services researchHypertensionMedical servicesPatientsResearch facilitiesResearch laboratories Issue Published: 1 August 1965 PDF DownloadLoading ...