Key result
Absence of trabecular hypertrophy/derangement and late gadolinium enhancement on cardiac MRI identified suspected arrhythmogenic cardiomyopathy patients with lower risk of disease progression.
Why the study?
To evaluate the predictive accuracy of trabecular hypertrophy/derangement and late gadolinium enhancement in predicting the diagnosis of arrhythmogenic cardiomyopathy.
Do imaging markers (trabecular hypertrophy/derangement and late gadolinium enhancement) predict future definite diagnosis of arrhythmogenic cardiomyopathy in suspected patients?
Cohort (n=59)
Do imaging markers (trabecular hypertrophy/derangement and late gadolinium enhancement) predict future definite diagnosis of arrhythmogenic cardiomyopathy in suspected patients?
The absence of trabecular hypertrophy/derangement and late gadolinium enhancement on cardiac MRI helps identify suspected arrhythmogenic cardiomyopathy patients at lower risk of disease progression.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for CMR markers in suspected AC; larger prospective studies needed before clinical adoption.
Aim: To evaluate the predictive accuracy of trabecular hypertrophy/derangement and late gadolinium enhancement in predicting diagnosis of arrhythmogenic cardiomyopathy (AC). Materials & methods: Fifty-nine suspected AC patients were evaluated. To evaluate the ability of these markers to detect patients fulfilling definite diagnosis at 4-year follow-up, sensitivity (Se), specificity (Sp), positive and negative predictive value (PPV and NPV) and predictive accuracy (PA) were calculated. Results: Presence of trabecular hypertrophy/derangement showed high NPV, while late gadolinium enhancement at cardiac MRI high Sp, NPV and PA. Their combination with symptoms and/or revised Task Force Criteria showed a high Sp, NPV and PA for definitive diagnosis during follow-up. Conclusion: In suspected AC patients, the absence of these markers allows to identify those with lower risk of disease progression.
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Monda et al. (2020) conducted a cohort in Suspected arrhythmogenic cardiomyopathy (n=59). Trabecular hypertrophy/derangement and late gadolinium enhancement on cardiac MRI vs. Absence of these imaging markers was evaluated on Definitive diagnosis of arrhythmogenic cardiomyopathy. Absence of trabecular hypertrophy/derangement and late gadolinium enhancement on cardiac MRI identified suspected arrhythmogenic cardiomyopathy patients with lower risk of disease progression.
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