Key result
Type 1 diabetes was associated with smaller thalamus volumes compared to controls (p=0.034), and signs of cerebral small vessel disease in these patients correlated with smaller gray matter volumes.
Why the study?
Type 1 diabetes has been linked to brain volume reductions and cerebral small vessel disease, but the relationship between normalized brain volumes and cerebral small vessel disease had not been examined previously.
Is cerebral small vessel disease associated with smaller brain volumes in adults with Type 1 diabetes?
Cross-Sectional (n=217)
Is cerebral small vessel disease associated with smaller brain volumes in adults with Type 1 diabetes?
Type 1 diabetes and associated cerebral small vessel disease are linked to reductions in specific brain volume fractions, suggesting structural brain changes in this population.
Answers are grounded in this paper and cite their sources.
May inform cerebral monitoring in type 1 diabetes; leaves open normalized volume–cSVD links pending prospective data.
Introduction: Type 1 diabetes has been linked to brain volume reductions as well as to cerebral small vessel disease (cSVD). This study concerns the relationship between normalized brain volumes (volume fractions) and cSVD, which has not been examined previously. Methods: We subjected brain magnetic resonance imaging studies of 187 adults of both sexes with Type 1 diabetes and 30 matched controls to volumetry and neuroradiological interpretation. Results: Participants with Type 1 diabetes had smaller thalami compared to controls without diabetes ( p = 0.034). In subgroup analysis of the Type 1 diabetes group, having any sign of cSVD was associated with smaller cortical ( p = 0.031) and deep gray matter volume fractions ( p = 0.029), but a larger white matter volume fraction ( p = 0.048). After correcting for age, the smaller putamen volume remained significant. Conclusions: We found smaller thalamus volume fractions in individuals with Type 1 diabetes as compared to those without diabetes, as well as reductions in brain volume fractions related to signs of cSVD in individuals with Type 1 diabetes.
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Claesson et al. (2024) conducted a cross-sectional in Type 1 diabetes (n=217). Type 1 diabetes vs. Controls without diabetes was evaluated on Normalized brain volumes (volume fractions) (p=0.034). Type 1 diabetes was associated with smaller thalamus volumes compared to controls (p=0.034), and signs of cerebral small vessel disease in these patients correlated with smaller gray matter volumes.
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