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October 23, 2025Open Access

Relations between retinal microvasculature by optical coherence tomography angiography and cerebral small vessel disease in individuals with type 1 diabetes

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Authors

ATAleksi TarkkonenIKIiris KyläheikoMEMarika I. Eriksson

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Overview

Observational analysis shows lower vessel densities in individuals with type 1 diabetes and cerebral microbleeds, indicating OCTA may aid cerebrovascular risk stratification.

Key Points

  • Lower retinal vessel densities relate to cerebral microbleeds in individuals with type 1 diabetes, highlighting potential diagnostic value of OCTA.
  • Individuals with type 1 diabetes exhibited lower SCP and DCP vessel densities compared to healthy controls with significant associations noted for age and diabetes duration.
  • Assessment using optical coherence tomography angiography and brain MRI identified key microvascular changes related to cerebrovascular health.
  • These findings suggest OCTA may assist in cerebrovascular risk stratification but does not predict white matter hyperintensities.

Cite This Study

Tarkkonen et al. (2025) studied this question.

synapsesocial.com/papers/68f9bad7d7353cfcfc68f608https://doi.org/10.1101/2025.10.20.25338353
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Associations between retinal microvasculature and cognition in middle-aged adults with type 1 diabetes without overt neurological symptoms2026
  2. 2Early Signs of Microvascular Impairment on Optical Coherence Tomography Angiography in Pediatric Patients With Type 1 Diabetes Without Clinical Retinopathy2026
  3. 3Retinal vascular density as a potential biomarker of diabetic cerebral small vessel disease2024 · 17 citations
  4. 4The relationship between carotid intima-media thickness and microvascular changes in retinal zones and optic disc in patients with type 1 diabetes mellitus2021 · 7 citations
  5. 5Diabetes May Modulate the Association Between Age and Optical Coherence Tomography Angiography Parameters: A Serial, Cross-Sectional Study2026