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March 14, 2026Journal of VitreoRetinal Diseases

Early Signs of Microvascular Impairment on Optical Coherence Tomography Angiography in Pediatric Patients With Type 1 Diabetes Without Clinical Retinopathy

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Authors

NBNiloufar BineshfarNGNahal GhaneABAudina M. Berrocal

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Overview

Meta-analysis shows altered foveal avascular zone and vessel densities in pediatric patients with type 1 diabetes, suggesting early screening needs.

Key Points

  • To assess microvascular changes using optical coherence tomography angiography in children with type 1 diabetes without clinical retinopathy.
  • Conducted a meta-analysis of observational studies
  • Included children with type 1 diabetes and age-matched controls
  • Analyzed data from 11 studies with standardized mean differences and random-effects modeling
  • Children with type 1 diabetes exhibited higher foveal avascular zone area and perimeter than healthy controls
  • Lower parafoveal and perifoveal vessel densities were found in diabetic patients
  • No significant differences in mean foveal and perifoveal capillary plexus vessel density compared to controls

Cite This Study

Bineshfar et al. (2026) studied this question.

synapsesocial.com/papers/69b4ada918185d8a3980145chttps://doi.org/10.1177/24741264261423307
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