Key result
The VEGFA rs35410204 CC genotype was associated with an approximately tenfold higher risk of bleeding complications during warfarin therapy in patients with mechanical heart valves.
Why the study?
The study was designed to identify the possible effects of VEGFA polymorphisms on bleeding complications in patients with mechanical heart valves who have achieved therapeutic INR.
Are VEGFA gene polymorphisms associated with bleeding complications in patients with mechanical heart valves maintaining therapeutic INR on warfarin?
Observational
Are VEGFA gene polymorphisms associated with bleeding complications in patients with mechanical heart valves maintaining therapeutic INR on warfarin?
Specific VEGFA gene polymorphisms are associated with a significantly higher risk of bleeding complications in patients with mechanical heart valves on warfarin, even when maintaining a therapeutic INR.
rs35410204 CC genotype linked to bleeding on therapeutic INR; leaves open whether VEGFA genotyping informs anticoagulation.
Aim: This study was designed to identify the possible effects of VEGFA polymorphisms on the occurrence of bleeding complications in patients with mechanical heart valves who have achieved therapeutic international normalized ratio (INR). Materials & methods: 13 SNPs of VEGFA were analyzed. Uni- and multi-variate analyses were conducted to identify associations between polymorphisms and bleeding complications. Results & conclusion: Patients with the CC genotype of rs35410204 had an approximately tenfold higher bleeding complication than those with the T allele. For rs866236, patients who had wild-type homozygotes showed an approximately 2.9-fold higher bleeding complication than C allele carriers. This study demonstrated that bleeding complications during warfarin therapy are associated with VEGFA polymorphisms in patients with mechanical heart valves.
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Yee et al. (2019) conducted an observational in Mechanical heart valves on warfarin therapy. VEGFA gene polymorphisms (rs35410204 CC genotype) vs. T allele was evaluated on Bleeding complications (tenfold higher). The VEGFA rs35410204 CC genotype was associated with an approximately tenfold higher risk of bleeding complications during warfarin therapy in patients with mechanical heart valves.
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