Molecular Genetic Significance of the Vegfa C-634g Gene Polymorphism in Predicting the Risk of Chronic Heart Failure Development in Patients With Ischemic Heart Disease

Q: What are the key findings of this study?

The C allele of the VEGFA C-634G polymorphism was significantly associated with a higher risk of severe chronic heart failure functional class IV compared to class III (OR 2.9, p=0.007).

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Chronic heart failure with ischemic heart disease (n=103). Intervention: VEGFA C-634G polymorphism (C allele) vs. VEGFA C-634G polymorphism (G allele). Primary outcome: Association of C allele with severe chronic heart failure (Functional Class IV vs III) (OR 2.9, 95% CI 1.31-6.23, p=0.007).

Q: What does this research mean for the field?

The VEGFA C-634G polymorphism is associated with chronic heart failure risk and clinical severity in patients with ischemic heart disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Мусашайхов У. Х.; N.I. Nasridinov

doi:10.67519/nshr.ztj.2026.03.076

July 15, 2026Journal of modern medicineOpen Access

Molecular Genetic Significance of the Vegfa C-634g Gene Polymorphism in Predicting the Risk of Chronic Heart Failure Development in Patients With Ischemic Heart Disease

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Key result

VEGFA C allele is linked to ~2.9-fold higher odds of class IV heart failure.

OR 2.9
95% CI 1.31-6.23
P=0.007
n=103

Why the study?

Identification of molecular genetic factors associated with the development and progression of chronic heart failure in ischemic heart disease patients is essential for early detection and personalized treatment.

Does the VEGFA C-634G polymorphism predict the severity of chronic heart failure development in patients with ischemic heart disease?

Key Points

To evaluate the molecular genetic significance of the VEGFA C-634G gene polymorphism in predicting the risk and clinical severity of chronic heart failure in patients with ischemic heart disease.
Genotyped the VEGFA C-634G polymorphism via real-time PCR using a Synthol LLC reagent kit on a Rotor-Gene Q system (QIAGEN, Germany).
Among patients with chronic heart failure functional class II versus functional class III, the frequencies of the wild G allele were 70.0% versus 82.0%, the homozygous G/G genotype was 51.5% versus 67.6%, and the heterozygous C/G genotype was 36.4% versus 29.7%.
No statistically significant differences in allele or genotype frequencies were identified between functional class comparison groups (chi-square > 3.84, p < 0.05).

Study Design

Type

Cross-Sectional (n=103)

Structured PICO

Does the VEGFA C-634G polymorphism predict the severity of chronic heart failure development in patients with ischemic heart disease?

P

Population

103 patients with chronic heart failure secondary to ischemic heart disease (57.3% female) evaluated for the association of VEGFA C-634G polymorphism with disease severity.

E

Exposure

VEGFA C-634G polymorphism (C allele and C/C or C/G genotypes)

C

Comparator

VEGFA C-634G polymorphism (wild-type G allele and G/G genotype)

O

Outcome

Severity of chronic heart failure functional class (FC IV vs FC III)surrogate

Main Result

Odds Ratio: 2.9 (95% CI 1.31–6.23)

Absolute Event Rate: 38% vs 18%

p-value: p=0.007

The VEGFA C-634G polymorphism (C allele) may serve as a potential genetic biomarker for predicting a more severe clinical course of chronic heart failure in patients with ischemic heart disease.

Implication

Should not yet guide genetic risk stratification in ischemic HF; leaves open validation in prospective cohorts.

Abstract

Chronic heart failure (CHF) developing on the background of ischemic heart disease (IHD) remains one of the leading causes of disability and mortality worldwide. Identification of molecular genetic factors associated with the development and progression of the disease is essential for the early detection of high-risk patients and the implementation of personalized prevention and treatment strategies. This article evaluates the molecular genetic significance of the VEGFA C-634G gene polymorphism in predicting the risk of CHF development in patients with IHD. The distribution of alleles and genotypes of the polymorphism, as well as their associations with clinical and functional parameters, were analyzed. The findings suggest that the VEGFA C-634G polymorphism may serve as an additional molecular genetic marker for assessing the risk of CHF development and the severity of its clinical course. Genotyping of the VEGFA C-634G polymorphism was performed using a commercial assay kit manufactured by Synthol LLC (Russia) on the Rotor-Gene Q real-time PCR system (QIAGEN, Germany).

Discussion

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Cite This Study

Х. et al. (2026) conducted a cross-sectional in Chronic heart failure with ischemic heart disease (n=103). VEGFA C-634G polymorphism (C allele) vs. VEGFA C-634G polymorphism (G allele) was evaluated on Association of C allele with severe chronic heart failure (Functional Class IV vs III) (OR 2.9, 95% CI 1.31-6.23, p=0.007). The C allele of the VEGFA C-634G polymorphism was significantly associated with a higher risk of severe chronic heart failure functional class IV compared to class III (OR 2.9, p=0.007).

synapsesocial.com/papers/6ad0fc7415427f6a840401b5 https://doi.org/10.67519/nshr.ztj.2026.03.076

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Molecular Genetic Significance of the Vegfa C-634g Gene Polymorphism in Predicting the Risk of Chronic Heart Failure Development in Patients With Ischemic Heart Disease

Key Points

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

Molecular Genetic Significance of the Vegfa C-634g Gene Polymorphism in Predicting the Risk of Chronic Heart Failure Development in Patients With Ischemic Heart Disease

Key Points

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

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