Why the study?
The prognosis of myocardial ischaemia with no obstructive coronary artery disease and its underlying vasomotor disorders, vasospastic angina and microvascular angina, is not well defined.
Comparison
VSA vs MVA and diagnostic methods for INOCA
Design
Systematic review and meta-analysis
Follow-up
Up to 5-year follow-up
Key result
Microvascular angina was associated with a higher rate of MACE compared to vasospastic angina (2.5 vs 1.1 per 100 patient-years; P=0.025), with no significant difference in death or MI.
Authors
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INOCA carries low overall MACE risk but higher rates in MVA with reduced CFR; high heterogeneity leaves precise prognosis open.
Meta-Analysis (n=17,302)
Absolute Event Rate: 2.5% vs 1.1%
p-value: p=0.025
Patients with INOCA generally have a low rate of MACE, but those with microvascular angina, particularly with reduced coronary flow reserve, face a significantly higher risk compared to other subgroups.
Odanović et al. (2024) conducted a meta-analysis in Ischaemia with no obstructive coronary artery disease (INOCA) (n=17,302). Microvascular angina (MVA) vs. Vasospastic angina (VSA) was evaluated on Major adverse cardiovascular event (MACE) (p=0.025). Microvascular angina was associated with a higher rate of MACE compared to vasospastic angina (2.5 vs 1.1 per 100 patient-years; P=0.025), with no significant difference in death or MI.