Key result
Heart rate variability was reduced in idiopathic Parkinson's disease versus controls (P<0.008 for low-frequency power) but remained intact in individuals with LRRK2-associated Parkinson's disease.
Why the study?
Does heart rate variability differ between LRRK2-associated Parkinson's disease, idiopathic Parkinson's disease, and controls?
Cross-Sectional (n=163)
Does heart rate variability differ between LRRK2-associated Parkinson's disease, idiopathic Parkinson's disease, and controls?
p-value: p=<.008
Heart rate variability remains intact in LRRK2-associated Parkinson's disease, unlike in idiopathic Parkinson's disease, suggesting clinical-pathologic differences between the two forms.
HRV appears preserved in LRRK2-PD unlike idiopathic PD; leaves open genotype-specific autonomic differences requiring prospective confirmation.
BACKGROUND: Heart rate variability is reduced in idiopathic PD, indicating cardiac autonomic dysfunction likely resulting from peripheral autonomic synucleinopathy. Little is known about heart rate variability in leucine-rich repeat kinase 2-associated PD. OBJECTIVES: This study investigated heart rate variability in LRRK2-associated PD. METHODS: Resting electrocardiograms were obtained from 20 individuals with LRRK2-associated PD, 37 nonmanifesting carriers, 48 related noncarriers, 26 idiopathic PD patients, and 32 controls. Linear regression modelling compared time and frequency domain values, adjusting for age, sex, heart rate, and disease duration. RESULTS: Low-frequency power and the ratio of low-high frequency power were reduced in idiopathic PD versus controls (P < .008, P < .029 respectively). In contrast, individuals with LRRK2-associated PD were not statistically different from controls in any parameter measured. Furthermore, all parameters trended toward being higher in LRRK2-associated PD when compared with idiopathic PD. CONCLUSIONS: Heart rate variability may remain intact in LRRK2-associated PD, adding to a growing literature supporting clinical-pathologic differences between LRRK2-associated and idiopathic PD.
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Visanji et al. (2017) conducted a cross-sectional in Parkinson's disease (n=163). LRRK2-associated Parkinson's disease vs. Idiopathic Parkinson's disease and healthy controls was evaluated on Heart rate variability (time and frequency domain values) (p=<.008). Heart rate variability was reduced in idiopathic Parkinson's disease versus controls (P<0.008 for low-frequency power) but remained intact in individuals with LRRK2-associated Parkinson's disease.
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