Key result
Idiopathic Parkinson's disease is linked to reduced HRV independent of disease duration or drug dosage.
Why the study?
Measures of heart rate variability in patients with idiopathic Parkinson’s disease needed verification to understand autonomic nervous system modulation alterations.
Does idiopathic Parkinson's disease alter heart rate variability compared to asymptomatic individuals?
Case-Control (n=72)
Does idiopathic Parkinson's disease alter heart rate variability compared to asymptomatic individuals?
Idiopathic Parkinson's disease is associated with reduced heart rate variability, suggesting altered autonomic nervous system modulation.
May indicate autonomic dysfunction in Parkinson's disease; hypothesis-generating for heart rate variability monitoring, pending prospective validation.
The aim of this study was to verify measures of heart rate variability in patients with idiopathic Parkinson’s disease. Seventy two male participants volunteered for the study, 36 with diagnosed Parkinson’s disease and 36 asymptomatic individuals. We conducted ambulatory recordings of 10 minutes in orthostatic position after five minutes of rest. Data was collected with POLAR RS800CX cardiac monitor and then analyzed by Kubios HRV 2.0 software to obtain measures of time and frequency domains. We found reductions in most part of collected indexes without correlation with disease duration or drugs dosage. The reductions of collected indexes reinforce the idea that Parkinson’s disease alters the autonomic nervous system modulation.
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Fabiano Henrique Rodrigues Soares (2013) conducted a case-control in Idiopathic Parkinson's disease (n=72). Idiopathic Parkinson's disease vs. Asymptomatic individuals was evaluated on Measures of heart rate variability (time and frequency domains). Idiopathic Parkinson's disease was associated with reductions in most heart rate variability indexes compared to asymptomatic individuals, without correlation to disease duration or drug dosage.
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