Key result
Idiopathic Parkinson's disease without autonomic symptoms is linked to reduced HRV during head-up tilt.
Why the study?
Cardiovascular autonomic functions in idiopathic Parkinson's disease without autonomic symptoms were not well characterized using heart rate variability and tilt testing.
Does idiopathic Parkinson's disease without autonomic symptoms affect heart rate variability and autonomic responses to passive tilt compared to healthy controls?
Case-Control (n=38)
Does idiopathic Parkinson's disease without autonomic symptoms affect heart rate variability and autonomic responses to passive tilt compared to healthy controls?
Patients with idiopathic Parkinson's disease without autonomic symptoms exhibit frequent impairment of autonomic nervous system function as measured by heart rate variability.
Suggests subclinical autonomic involvement in early Parkinson's; leaves open whether HRV monitoring aids prognosis or management.
OBJECTIVES: We evaluated time and spectral analyses of 24-h heart rate variability (HRV) and the heart rate responses to passive tilt in patients with idiopathic Parkinson's disease (IPD) in order to investigate cardiovascular autonomic functions. MATERIAL AND METHODS: Twenty-three subjects with IPD without autonomic symptoms and 15 age-matched healthy controls were enrolled. Frequency- and time-domain HRV parameters were studied during resting and passive head-up tilt (HUT) test. RESULTS: All time-domain parameters were found to be low in patients with IPD. In patients with IPD, both low frequency (LF) and high frequency (HF) decreased during HUT period and no significant change in LF to HF ratio was noted. Both time- and frequency-domain HRV indices showed no correlation with age, disease severity and duration, and with l-dopa medication. CONCLUSION: The results indicate that impairment of autonomic nervous system function in IPD without autonomic symptoms is frequent, and does not show clear association with clinical stage and the age of the patients.
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Mihçi et al. (2006) conducted a case-control in Idiopathic Parkinson's disease (n=38). Idiopathic Parkinson's disease vs. Age-matched healthy controls was evaluated on Time and spectral analyses of 24-h heart rate variability (HRV) and heart rate responses to passive tilt. Idiopathic Parkinson's disease without autonomic symptoms was associated with lower time-domain heart rate variability parameters and decreased low and high frequency during head-up tilt.
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