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The uniquely woven, highly strained molecular architecture and the potent antitumor activity of diazonamide A (1) make this natural product an attractive synthetic target. The key steps in this total synthesis of 1 include a novel SmI2-induced ring-closing cascade sequence and an unusual oxidation of an indoline to an oxindole in the presence of Pd(OH)2/C.
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Nicolaou et al. (2003) studied this question.
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