Key result
ATP-load cardiac MDCT successfully quantified myocardial blood flow, demonstrating significantly lower flow in territories with coronary stenosis (1.19 ml/g/min) compared to those without stenosis (2.06 ml/g/min).
Why the study?
Can cardiac multidetector-row computed tomography (MDCT) using the ATP-load technique quantitatively assess myocardial blood flow in patients with coronary artery disease?
Observational (n=14)
No
Can cardiac multidetector-row computed tomography (MDCT) using the ATP-load technique quantitatively assess myocardial blood flow in patients with coronary artery disease?
Absolute Event Rate: 1.19% vs 2.06%
p-value: p=<0.01
First-pass dynamic MDCT with ATP loading can feasibly quantify regional myocardial blood flow, distinguishing between ischemic and non-ischemic territories.
Supports feasibility of ATP-load MDCT for myocardial blood flow quantification; leaves open diagnostic accuracy and clinical utility pending validation.
BACKGROUND: The feasibility of using cardiac multidetector-row computed tomography (MDCT) technology in the quantitative assessment of myocardial blood flow (MBF) using the adenosine triphosphate (ATP) load technique was investigated in the present study. METHODS AND RESULTS: The study group comprised 14 patients (11 men, 3 women, age range 52-79 years, mean age 69.2 years) who underwent cardiac cine MDCT using the ATP-load technique. MBF was estimated from the slope of the linear regression equation with Patlak plots analysis. The overall average MBF was 1.83+/-0.62 ml . g(-1) . min(-1). Mean MBF in territories with stenosis on coronary angiography was 1.19+/-0.36 ml . g(-1) . min(-1) and 2.06+/-0.54 ml . g(-1) . min(-1) (p<0.01) in territories without stenosis. The average MBF in territories with moderate to severe ischemia on myocardial perfusion scintigraphy was 1.32+/-0.14 ml .g(-1 ). min(-1 )and 1.95+/-0.64 ml . g(-1) . min(-1) (p<0.01) in territories without ischemia. CONCLUSION: MDCT can be used to quantify MBF using first-pass dynamic data.
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Kido et al. (2008) conducted an observational in Coronary Artery Disease (n=14). ATP-load cardiac MDCT vs. Territories without stenosis was evaluated on Myocardial blood flow (MBF) in territories with vs without stenosis on coronary angiography (p=<0.01). ATP-load cardiac MDCT successfully quantified myocardial blood flow, demonstrating significantly lower flow in territories with coronary stenosis (1.19 ml/g/min) compared to those without stenosis (2.06 ml/g/min).
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